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2,2,6-TRIMETHYLCYCLOHEXANONE

  • Name 2,2,6-TRIMETHYLCYCLOHEXANONE
  • CAS 2408-37-9
  • Purity 99%
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Product Details

Manufacturer supply top purity 2,2,6-TRIMETHYLCYCLOHEXANONE 2408-37-9 with GMP standards

  • Molecular Formula: C9H16 O
  • Molecular Weight: 140.225
  • Appearance/Colour: CLEAR COLOURLESS LIQUID 
  • Vapor Pressure: 0.986mmHg at 25°C 
  • Melting Point: -31.8°C 
  • Refractive Index: n20/D 1.447(lit.)  
  • Boiling Point: 178-179 °C(lit.)  
  • Flash Point: 125 °F  
  • PSA： 17.07000 
  • Density: 0.904 g/mL at 25 °C(lit.)  
  • LogP: 2.40170 

2,2,6-TRIMETHYLCYCLOHEXANONE(Cas 2408-37-9) Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 4072, 1958 DOI: 10.1021/ja01548a061The Journal of Organic Chemistry, 27, p. 1615, 1962 DOI: 10.1021/jo01052a031

Purification Methods

Purify it via the semicarbazone (m 218o, from MeOH or EtOH), decompose this in the usual way (cf p 65 and 67, or MEK, p 106) and fractionally distil the liquid ketone through a vigreux column (p 11) at ~760mm. [Chakravarti J Chem Soc 1567 1947, Milas et al. J Am Chem Soc 70 1831 1948, Beilstein 7 I 24, 7 II 32, 7 III 7.]

Aroma threshold values

Detection: 100 ppb; recognition: 310 ppb

InChI:InChI=1/C9H16O/c1-7-5-4-6-9(2,3)8(7)10/h7H,4-6H2,1-3H3/t7-/m1/s1

2408-37-9 Relevant articles

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2408-37-9 Process route

2-Methylcyclohexanone
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2-Methylcyclohexanone

methyl iodide
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methyl iodide

2,6-dimethylcyclohexanone
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2,2-dimethyl-cyclohexanone
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2,2,6-trimethylcyclohexan-1-one
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2,2,6-trimethylcyclohexan-1-one

Conditions
Conditions Yield
With manganese(II) bromide; lithium hexamethyldisilazane; In tetrahydrofuran; for 14h; Ambient temperature;
5%
1%
89%
With manganese(II) bromide; lithium hexamethyldisilazane; In tetrahydrofuran; at 22 ℃; for 14h;
89%
1%
5%
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1-tri-n-butylstannyloxy-2-methylcyclohex-1-ene

(C<sub>4</sub>H<sub>9</sub>)3SnO(C<sub>6</sub>H<sub>8</sub>CH<sub>3</sub>)
41294-51-3

(C4 H9 )3SnO(C6 H8 CH3 )

2,6-dimethylcyclohexanone
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2,2-dimethyl-cyclohexanone
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2,2,6-trimethylcyclohexan-1-one
2408-37-9

2,2,6-trimethylcyclohexan-1-one

Conditions
Conditions Yield
With magnesium bromide; methyl iodide; In 1,2-dimethoxyethane; at 80°C, for 16 h; molar ratio of educts 55:45;
47%
29%
13%
With magnesium bromide; methyl iodide; In 1,2-dimethoxyethane; at 80°C, for 16 h; molar ratio of educts 15:85;
16%
47%
20%
With CH3I; MgBr2; In 1,2-dimethoxyethane; at 80°C, for 16 h; molar ratio of educts 55:45;
47%
29%
13%
With CH3I; MgBr2; In 1,2-dimethoxyethane; at 80°C, for 16 h; molar ratio of educts 15:85;
16%
47%
20%

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